Synthesis of novel substituted N-aryl benzamides as hA3G stabilizers and their inhibitory activities against hepatitis C virus replication

• Main Authors: Yanping Li (Author), Zonggen Peng (Author), Lanhu Hao (Author), Zhouyi Wu (Author), Yanping Zhu (Author), Laixing Hu (Author), Jiandong Jiang (Author), Zhuorong Li (Author)
• Format: Book
• Published: Elsevier, 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel amino-substituted N-aryl benzamide analogs were synthesized and evaluated for their ability to inhibit hepatitis C virus (HCV) replication in acutely infected Huh7.5 cells. Most of the substituted N-aryl benzamide compounds showed convincing anti-HCV activities. Compounds 1f, 1g an...