Soluble F proteins exacerbate pulmonary histopathology after vaccination upon respiratory syncytial virus challenge but not when presented on virus-like particles

• Main Authors: Youri Lee (Author), Young-Tae Lee (Author), Eun-Ju Ko (Author), Ki-Hye Kim (Author), Hye Suk Hwang (Author), Soojin Park (Author), Young-Man Kwon (Author), Sang Moo Kang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Respiratory syncytial virus (RSV) fusion (F) protein is suggested to be a protective vaccine target although its efficacy and safety concerns remain not well understood. We investigated immunogenicity, efficacy, and safety of F proteins in a soluble form or on virus-like particle (F-VLP). F VLP pref...