Soluble F proteins exacerbate pulmonary histopathology after vaccination upon respiratory syncytial virus challenge but not when presented on virus-like particles

• Hoofdauteurs: Youri Lee (Auteur), Young-Tae Lee (Auteur), Eun-Ju Ko (Auteur), Ki-Hye Kim (Auteur), Hye Suk Hwang (Auteur), Soojin Park (Auteur), Young-Man Kwon (Auteur), Sang Moo Kang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2017-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Respiratory syncytial virus (RSV) fusion (F) protein is suggested to be a protective vaccine target although its efficacy and safety concerns remain not well understood. We investigated immunogenicity, efficacy, and safety of F proteins in a soluble form or on virus-like particle (F-VLP). F VLP pref...