A Correlative Model to Predict In Vivo AUC for Nanosystem Drug Delivery with Release Rate-Limited Absorption

• Main Authors: Mohammad Barzegar-Jalali (Author), Kaivan Mohammadi (Author), Ghobad Mohammadi (Author), Hadi Valizadeh (Author), Azim Barzegar-Jalali (Author), Khosro Adibkia (Author), Ali Nokhodchi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo. Methods. A novel in vitro in vivo correlation, I...