Alvespimycin Exhibits Potential Anti-TGF-β Signaling in the Setting of a Proteasome Activator in Rats with Bleomycin-Induced Pulmonary Fibrosis: A Promising Novel Approach

• Main Authors: Osama A. Mohammed (Author), Mustafa Ahmed Abdel-Reheim (Author), Lobna A. Saleh (Author), Mohannad Mohammad S. Alamri (Author), Jaber Alfaifi (Author), Masoud I. E. Adam (Author), Alshaimaa A. Farrag (Author), AbdulElah Al Jarallah AlQahtani (Author), Waad Fuad BinAfif (Author), Abdullah A. Hashish (Author), Sameh Abdel-Ghany (Author), Elsayed A. Elmorsy (Author), Hend S. El-wakeel (Author), Ahmed S. Doghish (Author), Rabab S. Hamad (Author), Sameh Saber (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Idiopathic pulmonary fibrosis (IPF) is an irreversible and life-threatening lung disease of unknown etiology presenting only a few treatment options. TGF-β signaling orchestrates a cascade of events driving pulmonary fibrosis (PF). Notably, recent research has affirmed the augmentation of TGF-β rece...