Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

• Main Authors: David Ladrón de Guevara-Miranda (Author), Carmelo Millón (Author), Cristina Rosell-Valle (Author), Mercedes Pérez-Fernández (Author), Michele Missiroli (Author), Antonia Serrano (Author), Francisco J. Pavón (Author), Fernando Rodríguez de Fonseca (Author), Magdalena Martínez-Losa (Author), Manuel Álvarez-Dolado (Author), Luis J. Santín (Author), Estela Castilla-Ortega (Author)
• Format: Book
• Published: The Company of Biologists, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cocaine addiction disorder is notably aggravated by concomitant cognitive and emotional pathology that impedes recovery. We studied whether a persistent cognitive/emotional dysregulation in mice withdrawn from cocaine holds a neurobiological correlate within the hippocampus, a limbic region with a k...