Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures

• Main Authors: Yulin Duan (Author), Weiguang Sun (Author), Yongqi Li (Author), Zhengyi Shi (Author), Lanqin Li (Author), Yeting Zhang (Author), Kun Huang (Author), Zhiping Zhang (Author), Changxing Qi (Author), Yonghui Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor necrosis factor-α (TNF-α) is a promising target for inflammatory and autoimmune diseases. Spirohypertones A (1) and B (2), two unprecedented polycyclic polyprenylated acylphloroglucinols with highly rearranged skeletons, were isolated from Hypericum patulum. The structures of 1 and 2 were conf...