Mutations in <i>embB</i>406 Are Associated with Low-Level Ethambutol Resistance in Canadian <i>Mycobacterium tuberculosis</i> Isolates

• Main Authors: Morgan Hiebert (Author), Meenu K. Sharma (Author), Melissa Rabb (Author), Lisa Karlowsky (Author), Kiana Bergman (Author), Hafid Soualhine (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In <i>Mycobacterium tuberculosis</i>, molecular predictions of ethambutol resistance rely primarily on the detection of mutations within <i>embB</i>. However, discordance between <i>embB</i>406 mutations and gold standard phenotypic drug sensitivity testing (DST)...