Costunolide induces mitochondria-mediated apoptosis in human gastric adenocarcinoma BGC-823 cells

• Main Authors: Zhanpeng Yan (Author), Tingting Xu (Author), Zhentao An (Author), Ying Hu (Author), Wanzhen Chen (Author), Jinxia Ma (Author), Changle Shao (Author), Fangshi Zhu (Author)
• Format: Book
• Published: BMC, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Costunolide, a sesquiterpene lactone extracted from Radix Aucklandiae, has the activity against multiple cancers. However, the effect of costunolide on gastric cancer (GC) have remained to be ambiguous. In this study, we investigated the underlying mechanisms of apoptosis induced...