A Japanese case of castration-resistant prostate cancer with BRCA2 and RB1 co-loss and TP53 mutation: a case report

• Autori principali: Tomohiro Iwasawa (Autore), Takeo Kosaka (Autore), Shinya Morita (Autore), Shuji Mikami (Autore), Kohei Nakamura (Autore), Hiroshi Hongo (Autore), Hiroshi Nishihara (Autore), Mototsugu Oya (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2022-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background Abnormalities in homologous recombination contribute to the aggressive nature of castration-resistant prostate cancer. Retinoblastoma transcriptional corepressor 1 (RB1) and breast cancer 2 (BRCA2) exist close to each other in the same chromosome, and the significance of their co...