Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level

• Main Authors: Shay Leary (Author), Silvana Gaudieri (Author), Matthew Parker (Author), Abha Chopra (Author), Ian James (Author), Suman Pakala (Author), Eric Alves (Author), Mina John (Author), Benjamin Lindsey (Author), Alexander Keeley (Author), Sarah Rowland-Jones (Author), Maurice Swanson (Author), David Ostrov (Author), Jodi Bubenik (Author), Suman Das (Author), John Sidney (Author), Alessandro Sette (Author), COVID-19 Genomics UK (COG-UK) (Author), Thushan de Silva (Author), Elizabeth Phillips (Author), Simon Mallal (Author)
• Format: Book
• Published: Case Western Reserve University, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Genetic variations across the SARS-CoV-2 genome may influence transmissibility of the virus and the host's anti-viral immune response, in turn affecting the frequency of variants over time. In this study, we examined the adjacent amino acid polymorphisms in the nucleocapsid (R203K/G...