Butyrate-treatment induces gingival epithelial cell death in a three-dimensional gingival-connective tissue hybrid co-culture system

• Main Authors: Yusuke Kurosawa (Author), Hirofumi Yamaguchi (Author), Kazuki Uemichi (Author), Keiji Shinozuka (Author), Yuki Kirihara (Author), Hiromasa Tsuda (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Three-dimensional (3D) cell culture systems are reported to be more physiologically similar to the in vivo state than 2-dimensional (2D) models, which are extensively employed in periodontal research. Herein, we developed a 3D gingival tissue model with both epithelial and lamina propria layers usin...