LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling

• Main Authors: Emilio R. Mustafá (Author), Santiago Cordisco González (Author), Marjorie Damian (Author), Sonia Cantel (Author), Severine Denoyelle (Author), Renaud Wagner (Author), Helgi B. Schiöth (Author), Jean-Alain Fehrentz (Author), Jean-Louis Banères (Author), Mario Perelló (Author), Jesica Raingo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 receptor (D2R). A key target of GHSR in neurons is...