A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice.

• Main Authors: Md Abu Sayeed (Author), Meagan Kelly Bufano (Author), Peng Xu (Author), Grace Eckhoff (Author), Richelle C Charles (Author), Mohammad Murshid Alam (Author), Tania Sultana (Author), Md Rasheduzzaman Rashu (Author), Amanda Berger (Author), Geoffrey Gonzalez-Escobedo (Author), Anjali Mandlik (Author), Taufiqur Rahman Bhuiyan (Author), Daniel T Leung (Author), Regina C LaRocque (Author), Jason B Harris (Author), Stephen B Calderwood (Author), Firdausi Qadri (Author), W F Vann (Author), Pavol Kováč (Author), Edward T Ryan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of lipopolysaccharide (LPS). METHODOLOGY:Here we describe a conjugate vaccine for cholera...