A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice.

• Główni autorzy: Md Abu Sayeed (Autor), Meagan Kelly Bufano (Autor), Peng Xu (Autor), Grace Eckhoff (Autor), Richelle C Charles (Autor), Mohammad Murshid Alam (Autor), Tania Sultana (Autor), Md Rasheduzzaman Rashu (Autor), Amanda Berger (Autor), Geoffrey Gonzalez-Escobedo (Autor), Anjali Mandlik (Autor), Taufiqur Rahman Bhuiyan (Autor), Daniel T Leung (Autor), Regina C LaRocque (Autor), Jason B Harris (Autor), Stephen B Calderwood (Autor), Firdausi Qadri (Autor), W F Vann (Autor), Pavol Kováč (Autor), Edward T Ryan (Autor)
• Format: Książka
• Wydane: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

BACKGROUND:Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of lipopolysaccharide (LPS). METHODOLOGY:Here we describe a conjugate vaccine for cholera...