CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD⁺-Lowering Agents

• मुख्य लेखकों: Pamela Becherini (लेखक), Debora Soncini (लेखक), Silvia Ravera (लेखक), Elisa Gelli (लेखक), Claudia Martinuzzi (लेखक), Giulia Giorgetti (लेखक), Antonia Cagnetta (लेखक), Fabio Guolo (लेखक), Federico Ivaldi (लेखक), Maurizio Miglino (लेखक), Sara Aquino (लेखक), Katia Todoerti (लेखक), Antonino Neri (लेखक), Andrea Benzi (लेखक), Mario Passalacqua (लेखक), Alessio Nencioni (लेखक), Ida Perrotta (लेखक), Maria Eugenia Gallo Cantafio (लेखक), Nicola Amodio (लेखक), Antonio De Flora (लेखक), Santina Bruzzone (लेखक), Roberto M. Lemoli (लेखक), Michele Cea (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Cancer cells fuel growth and energy demands by increasing their NAD⁺ biosynthesis dependency, which therefore represents an exploitable vulnerability for anti-cancer strategies. CD38 is a NAD⁺-degrading enzyme that has become crucial for anti-MM therapie...