Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a

• Main Authors: Huili Huang (Author), Ming Xie (Author), Li Gao (Author), Wenhui Zhang (Author), Xiaojia Zhu (Author), Yuwei Wang (Author), Wei Li (Author), Rongrong Wang (Author), Kesu Chen (Author), Mohamed Boutjdir (Author), Long Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was designed to investigate the hemodynamic effect of rolipram, a phosphodiesterase type 4 (PDE4) inhibitor, in normal rat hearts both in vivo and in vitro and its underlying mechanism. The pressure-volume loop, isolated heart, and Ca2+ transients triggered by field stimulation or caffein...