Pioglitazone improves visceral sensation and colonic permeability in a rat model of irritable bowel syndrome

• Main Authors: Tsukasa Nozu (Author), Saori Miyagishi (Author), Rintaro Nozu (Author), Kaoru Takakusaki (Author), Toshikatsu Okumura (Author)
• Format: Book
• Published: Elsevier, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visceral hypersensitivity and impaired gut barrier with minor inflammation are considered to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Since pioglitazone is known to have anti-inflammatory property, we hypothesized that pioglitazone is beneficial for treating I...