Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA

• Main Authors: Grant R. Campbell (Author), Pratima Rawat (Author), Stephen A. Spector (Author)
• Format: Book
• Published: Karger Publishers, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macrophages promote an early host response to infection by releasing pro-inflammatory cytokines such as interleukin (IL) 1β (IL-1β), tumour necrosis factor (TNF), and IL-6. One of the mechanisms through which cells sense pathogenic microorganisms is through Toll-like receptors (TLRs). IL-1 receptor-...