Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

• Main Authors: Chao Liu (Author), Keith P. Gates (Author), Longhou Fang (Author), Marcelo J. Amar (Author), Dina A. Schneider (Author), Honglian Geng (Author), Wei Huang (Author), Jungsu Kim (Author), Jennifer Pattison (Author), Jian Zhang (Author), Joseph L. Witztum (Author), Alan T. Remaley (Author), P. Duc Dong (Author), Yury I. Miller (Author)
• Format: Book
• Published: The Company of Biologists, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apolipoprotein C-II (APOC2) is an obligatory activator of lipoprotein lipase. Human patients with APOC2 deficiency display severe hypertriglyceridemia while consuming a normal diet, often manifesting xanthomas, lipemia retinalis and pancreatitis. Hypertriglyceridemia is also an important risk factor...