Applying Supercritical Fluid Technology to Prepare Ibuprofen Solid Dispersions with Improved Oral Bioavailability

• Autori principali: Fei Han (Autore), Wei Zhang (Autore), Ying Wang (Autore), Ziyue Xi (Autore), Lu Chen (Autore), Sanming Li (Autore), Lu Xu (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2019-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

In this study, supercritical fluid (SCF) technology was applied to prepare reliable solid dispersions of pharmaceutical compounds with limited bioavailability using ibuprofen (IBU) as a model compound. Solid-state characterization of the dispersions was conducted by differential scanning calorimetry...