Applying Supercritical Fluid Technology to Prepare Ibuprofen Solid Dispersions with Improved Oral Bioavailability

• Egile Nagusiak: Fei Han (Egilea), Wei Zhang (Egilea), Ying Wang (Egilea), Ziyue Xi (Egilea), Lu Chen (Egilea), Sanming Li (Egilea), Lu Xu (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2019-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

In this study, supercritical fluid (SCF) technology was applied to prepare reliable solid dispersions of pharmaceutical compounds with limited bioavailability using ibuprofen (IBU) as a model compound. Solid-state characterization of the dispersions was conducted by differential scanning calorimetry...