Pharmacokinetic/Pharmacodynamic Evaluation of Aztreonam/Amoxicillin/Clavulanate Combination against New Delhi Metallo-β-Lactamase and Serine-β-Lactamase Co-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>

• Main Authors: Jiayuan Zhang (Author), Mengyuan Wu (Author), Shuo Diao (Author), Shixing Zhu (Author), Chu Song (Author), Jiali Yue (Author), Frederico S. Martins (Author), Peijuan Zhu (Author), Zhihua Lv (Author), Yuanqi Zhu (Author), Mingming Yu (Author), Sherwin K. B. Sy (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to examine specific niches and usage for the aztreonam/amoxicillin/clavulanate combination and to use population pharmacokinetic simulations of clinical dosing regimens to predict the impact of this combination on restricting mutant selection. The in vitro susceptibility of 19 New-D...