Genotype frequencies of polymorphic MDR1 variants in the Kazakhstani population

• Main Authors: Samat Kozhakhmetov (Author), Adil Supiyev (Author), Almagul Kushugulova (Author), Indira Tynybayeva (Author), Alibek Kossumov (Author), Leila Utepova (Author), Saule Saduakhasova (Author), Gulnara Shakhabayeva (Author), Talgat Nurgozhin (Author), Zhaxybay Zhumadilov (Author)
• Format: Book
• Published: University Library System, University of Pittsburgh, 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Statins appear to be handled by an ATP-dependent membrane transporter and three SNPs (C1236T (rs1128503), G2677T (rs2032582), and C3435T (rs1045642), which capture the common genetic variation at this locus. Individuals, who carry the T allele at each SNP (i.e., the T-T-T haplotype), h...