Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice

• Main Authors: Shiori MINABE (Author), Sho NAKAMURA (Author), Eri FUKUSHIMA (Author), Marimo SATO (Author), Kana IKEGAMI (Author), Teppei GOTO (Author), Makoto SANBO (Author), Masumi HIRABAYASHI (Author), Junko TOMIKAWA (Author), Takuya IMAMURA (Author), Naoko INOUE (Author), Yoshihisa UENOYAMA (Author), Hiroko TSUKAMURA (Author), Kei-Ichiro MAEDA (Author), Fuko MATSUDA (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulating evidence suggests that kisspeptin-GPR54 signaling is indispensable for gonadotropin-releasing hormone (GnRH)/gonadotropin secretion and consequent reproductive functions in mammals. Conventional Kiss1 knockout (KO) mice and rats are reported to be infertile. To date, however, no study h...