Long-Term Enhancement of NMDA Receptor Function in Inhibitory Neurons Preferentially Modulates Potassium Channels and Cell Adhesion Molecules

• Main Authors: Dan Xia (Author), Xinyang Zhang (Author), Di Deng (Author), Xiaoyan Ma (Author), Samer Masri (Author), Jianzheng Wang (Author), Shaowen Bao (Author), Songnian Hu (Author), Qiang Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Effectively enhancing the activity of inhibitory neurons has great therapeutic potentials since their reduced function/activity has significant contributions to pathology in various brain diseases. We showed previously that NMDAR positive allosteric modulator GNE-8324 and M-8324 selectively increase...