pKa-critical Interpretations of Solubility-pH Profiles: PG 300995 and NSC-639829 Case Studies
Two weak bases, PG-300995 (anti-HIV agent) and NSC-639829 (anti-tumor agent), whose log S - pH profiles had been previously published, but whose pKa values had not been reported, were analyzed using a method which can determine pKa values from log S - pH data. This "SpH-pKa" technique, alt...
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International Association of Physical Chemists (IAPC),
2015-07-01T00:00:00Z.
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