Comprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant

• Main Authors: Hyeong-Jun Park (Author), Hae Li Ko (Author), Dong-Hoon Won (Author), Da-Bin Hwang (Author), Yoo-Sub Shin (Author), Hye-Won Kwak (Author), Hye-Jung Kim (Author), Jun-Won Yun (Author), Jae-Hwan Nam (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adjuvants enhance the efficacy of vaccines by stimulating immune response-related gene expression and pathways. Although some adjuvants have been approved for commercial use in human vaccines (e.g., Alum, MF59, and AS03), they might elicit adverse side effects, such as autoimmune diseases. Recently,...