Altered expression of transcription factors IRF4 and IRF8 in peripheral blood B cells is associated with clinical severity and circulating plasma cells frequency in patients with myasthenia gravis

• Main Authors: Yong Zhang (Author), Xiao Jia (Author), Yan Xia (Author), Hao Li (Author), Fei Chen (Author), Jie Zhu (Author), Xiuying Zhang (Author), Yanyan Zhang (Author), YuZhong Wang (Author), Yanan Xu (Author), Meng Pan (Author), Xiaoyu Huang (Author), Tingyan Yu (Author), Linlin Fu (Author), Chenghua Xiao (Author), Deqin Geng (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous studies have shown that interferon regulatory factor-4 (IRF4) and IRF8 play critical but distinct roles in the differentiation of B cells into plasma cells (PCs). In the present study, we aimed to measure the expression levels of IRF4 and IRF8 in B cells from patients with myasthenia gravis...