Rapid and Sensitive Detection of Breast Cancer Cells in Patient Blood with Nuclease-Activated Probe Technology

• Main Authors: Sven Kruspe (Author), David D. Dickey (Author), Kevin T. Urak (Author), Giselle N. Blanco (Author), Matthew J. Miller (Author), Karen C. Clark (Author), Elliot Burghardt (Author), Wade R. Gutierrez (Author), Sneha D. Phadke (Author), Sukriti Kamboj (Author), Timothy Ginader (Author), Brian J. Smith (Author), Sarah K. Grimm (Author), James Schappet (Author), Howard Ozer (Author), Alexandra Thomas (Author), James O. McNamara, II (Author), Carlos H. Chan (Author), Paloma H. Giangrande (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A challenge for circulating tumor cell (CTC)-based diagnostics is the development of simple and inexpensive methods that reliably detect the diverse cells that make up CTCs. CTC-derived nucleases are one category of proteins that could be exploited to meet this challenge. Advantages of nucleases as...