Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction

• Main Authors: Thomas Kunzke (Author), Achim Buck (Author), Verena M. Prade (Author), Annette Feuchtinger (Author), Olga Prokopchuk (Author), Marc E. Martignoni (Author), Simone Heisz (Author), Hans Hauner (Author), Klaus‐Peter Janssen (Author), Axel Walch (Author), Michaela Aichler (Author)
• Format: Book
• Published: Wiley, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cachexia is the direct cause of at least 20% of cancer‐associated deaths. Muscle wasting in skeletal muscle results in weakness, immobility, and death secondary to impaired respiratory muscle function. Muscle proteins are massively degraded in cachexia; nevertheless, the molecula...