A Splice Variant of ASC Regulates IL-1β Release and Aggregates Differently from Intact ASC

• Main Authors: Kazuhiko Matsushita (Author), Michiko Takeoka (Author), Junji Sagara (Author), Naoki Itano (Author), Yuka Kurose (Author), Akihiro Nakamura (Author), Shun'ichiro Taniguchi (Author)
• Format: Book
• Published: Hindawi Limited, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recrui...