Mismatched single stranded antisense oligonucleotides can induce efficient dystrophin splice switching

• Main Authors: Kole Ryszard (Author), Fletcher Sue (Author), Johnsen Russell D (Author), Adams Abbie M (Author), Fragall Clayton T (Author), Wilton Steve D (Author)
• Format: Book
• Published: BMC, 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Antisense oligomer induced exon skipping aims to reduce the severity of Duchenne muscular dystrophy by redirecting splicing during pre-RNA processing such that the causative mutation is by-passed and a shorter but partially functiona...