Molecular Generation for Desired Transcriptome Changes With Adversarial Autoencoders

• Main Authors: Rim Shayakhmetov (Author), Maksim Kuznetsov (Author), Alexander Zhebrak (Author), Artur Kadurin (Author), Sergey Nikolenko (Author), Alexander Aliper (Author), Daniil Polykovskiy (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene expression profiles are useful for assessing the efficacy and side effects of drugs. In this paper, we propose a new generative model that infers drug molecules that could induce a desired change in gene expression. Our model-the Bidirectional Adversarial Autoencoder-explicitly separates cellul...