Molecular Generation for Desired Transcriptome Changes With Adversarial Autoencoders
Gene expression profiles are useful for assessing the efficacy and side effects of drugs. In this paper, we propose a new generative model that infers drug molecules that could induce a desired change in gene expression. Our model-the Bidirectional Adversarial Autoencoder-explicitly separates cellul...
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Main Authors: | Rim Shayakhmetov (Author), Maksim Kuznetsov (Author), Alexander Zhebrak (Author), Artur Kadurin (Author), Sergey Nikolenko (Author), Alexander Aliper (Author), Daniil Polykovskiy (Author) |
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Format: | Book |
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Frontiers Media S.A.,
2020-04-01T00:00:00Z.
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