Development and Pharmacokinetic Evaluation of Novasomes for the Trans-nasal Delivery of Fluvoxamine Using Arachidonic Acid-Carboxymethyl Chitosan Conjugate

• Main Authors: Saima Gulshan (Author), Shahid Shah (Author), Pervaiz Akhtar Shah (Author), Muhammad Irfan (Author), Malik Saadullah (Author), Ghulam Abbas (Author), Muhammad Hanif (Author), Akhtar Rasul (Author), Nabeel Ahmad (Author), Abid Mahmood (Author), Ejaz Basheer (Author), Mohammad Omer Habib (Author), Hadil Faris Alotaibi (Author), Ahmad J. Obaidullah (Author), Jawza F. Alsabhan (Author), Osama l. Alwassil (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Depression is the major mental illness which causes along with loss of interest in daily life, a feeling of hopelessness, appetite or weight changes, anger and irritability. Due to the hepatic first-pass metabolism, the absolute bioavailability of fluvoxamine (FVM) after oral administration is about...