Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

• Main Authors: Valérie Schreiber (Author), Reuben Mercier (Author), Sara Jiménez (Author), Tao Ye (Author), Emmanuel García-Sánchez (Author), Annabelle Klein (Author), Aline Meunier (Author), Sabitri Ghimire (Author), Catherine Birck (Author), Bernard Jost (Author), Kristian Honnens de Lichtenberg (Author), Christian Honoré (Author), Palle Serup (Author), Gérard Gradwohl (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In humans, homozygous mutations of NEUROG3 manifest with neonatal or childhood diabetes. Despite this critical role i...