Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats

• Main Authors: Wei-ren Lan (Author), Sai Pan (Author), Hai-yin Li (Author), Chao Sun (Author), Xian Chang (Author), Kang Lu (Author), Chang-qing Jiang (Author), Rui Zuo (Author), Yue Zhou (Author), Chang-qing Li (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stem cell therapies for intervertebral disc degeneration have been demonstrated as a promising strategy. Previous studies have shown that human nucleus pulposus cell- (NPC-) derived exosomes can induce the differentiation of mesenchymal stem cells (MSCs) into NP-like cells in vitro. However, the mec...