Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats

• मुख्य लेखकों: Wei-ren Lan (लेखक), Sai Pan (लेखक), Hai-yin Li (लेखक), Chao Sun (लेखक), Xian Chang (लेखक), Kang Lu (लेखक), Chang-qing Jiang (लेखक), Rui Zuo (लेखक), Yue Zhou (लेखक), Chang-qing Li (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Hindawi Limited, 2019-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Stem cell therapies for intervertebral disc degeneration have been demonstrated as a promising strategy. Previous studies have shown that human nucleus pulposus cell- (NPC-) derived exosomes can induce the differentiation of mesenchymal stem cells (MSCs) into NP-like cells in vitro. However, the mec...