Pharmacokinetics and Drug-Drug Interactions of Abacavir and Lamuvudine Co-administered With Antituberculosis Drugs in HIV-Positive Children Treated for Multidrug-Resistant Tuberculosis

• Main Authors: Louvina E. van der Laan (Author), Anthony J. Garcia-Prats (Author), H. Simon Schaaf (Author), Jana L. Winckler (Author), Heather Draper (Author), Jennifer Norman (Author), Lubbe Wiesner (Author), Helen McIlleron (Author), Paolo Denti (Author), Anneke C. Hesseling (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Given the high prevalence of multidrug-resistant (MDR)-TB in high HIV burden settings, it is important to identify potential drug-drug interactions between MDR-TB treatment and widely used nucleoside reverse transcriptase inhibitors (NRTIs) in HIV-positive children. Population pharmacokinetic models...