Transporter-Mediated Drug Interaction Strategy for 5-Aminolevulinic Acid (ALA)-Based Photodynamic Diagnosis of Malignant Brain Tumor: Molecular Design of ABCG2 Inhibitors

• Main Authors: Toshihisa Ishikawa (Author), Shin-ichi Miyatake (Author), Toshihiko Kuroiwa (Author), Shun-ichiro Ogura (Author), Yuichiro Hagiya (Author), Yoshinaga Kajimoto (Author), Naokado Ikeda (Author), Kenkichi Takahashi (Author)
• Format: Book
• Published: MDPI AG, 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Photodynamic diagnosis (PDD) is a practical tool currently used in surgical operation of aggressive brain tumors, such as glioblastoma. PDD is achieved by a photon-induced physicochemical reaction which is induced by excitation of protoporphyrin IX (PpIX) exposed to light. Fluorescence-guided gross-...