Mechanistic Insights into Side Effects of Troglitazone and Rosiglitazone Using a Novel Inverse Molecular Docking Protocol

• Huvudskapare: Katarina Kores (Författare, medförfattare), Janez Konc (Författare, medförfattare), Urban Bren (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: MDPI AG, 2021-02-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

Thiazolidinediones form drugs that treat insulin resistance in type 2 diabetes mellitus. Troglitazone represents the first drug from this family, which was removed from use by the FDA due to its hepatotoxicity. As an alternative, rosiglitazone was developed, but it was under the careful watch of FDA...