A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression

• मुख्य लेखकों: Yongrui Hai (लेखक), Renming Fan (लेखक), Ting Zhao (लेखक), Ruizhuo Lin (लेखक), Junyan Zhuang (लेखक), Aohua Deng (लेखक), Shanshui Meng (लेखक), Zhuang Hou (लेखक), Gaofei Wei (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2024-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Dihydroorotate dehydrogenase (DHODH)-mediated ferroptosis defense is a targetable vulnerability in cancer. Currently, only a few DHODH inhibitors have been utilized in clinical practice. To further enhance DHODH targeting, we introduced the mitochondrial targeting group triphenylphosphine (TPP) to b...