A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression

• Main Authors: Yongrui Hai (Author), Renming Fan (Author), Ting Zhao (Author), Ruizhuo Lin (Author), Junyan Zhuang (Author), Aohua Deng (Author), Shanshui Meng (Author), Zhuang Hou (Author), Gaofei Wei (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dihydroorotate dehydrogenase (DHODH)-mediated ferroptosis defense is a targetable vulnerability in cancer. Currently, only a few DHODH inhibitors have been utilized in clinical practice. To further enhance DHODH targeting, we introduced the mitochondrial targeting group triphenylphosphine (TPP) to b...