Characterization of PF-6142, a Novel, Non-Catecholamine Dopamine Receptor D1 Agonist, in Murine and Nonhuman Primate Models of Dopaminergic Activation

• 主要な著者: Rouba Kozak (著者), Tamás Kiss (著者), Keith Dlugolenski (著者), David E. Johnson (著者), Roxanne R. Gorczyca (著者), Kyle Kuszpit (著者), Brian D. Harvey (著者), Polina Stolyar (著者), Stacey J. Sukoff Rizzo (著者), William E. Hoffmann (著者), Dmitri Volfson (著者), Mihaly Hajós (著者), Jennifer E. Davoren (著者), Amanda L. Abbott (著者), Graham V. Williams (著者), Stacy A. Castner (著者), David L. Gray (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Selective activation of dopamine D1 receptors remains a promising pro-cognitive therapeutic strategy awaiting robust clinical investigation. PF-6142 is a key example from a recently disclosed novel series of non-catechol agonists and partial agonists of the dopamine D1/5 receptors (D1R) that exhibit...