A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain

• Main Authors: Juan Chen (Author), Yang Zhuang (Author), Ya Zhang (Author), Huabao Liao (Author), Rui Liu (Author), Jing Cheng (Author), Zhifeng Zhang (Author), Jiangdong Sun (Author), Jingchen Gao (Author), Xiyuran Wang (Author), Shujun Chen (Author), Liang Zhang (Author), Fengyuan Che (Author), Qi Wan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: We and others have previously demonstrated that glycine is neuroprotective in cerebral ischemia-reperfusion injury. But glycine has low permeability to the blood-brain barrier (BBB). To deliver glycine into the ischemic brain to confer neuroprotection, we designed a novel glycine-contain...