KLRG1 expression identifies short-lived Foxp3+ Treg effector cells with functional plasticity in islets of NOD mice

• Prif Awduron: Mara Kornete (Awdur), Edward Mason (Awdur), Roman Istomine (Awdur), Ciriaco A. Piccirillo (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2017-08-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

A progressive waning in Foxp3+ regulatory T (Treg) cell function provokes autoimmunity in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D), a cellular defect rescued by prophylactic IL-2 therapy. We showed that most islet-infiltrating Treg cells express inducible T-cell co-stimulato...