KLRG1 expression identifies short-lived Foxp3+ Treg effector cells with functional plasticity in islets of NOD mice

A progressive waning in Foxp3+ regulatory T (Treg) cell function provokes autoimmunity in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D), a cellular defect rescued by prophylactic IL-2 therapy. We showed that most islet-infiltrating Treg cells express inducible T-cell co-stimulato...

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Main Authors: Mara Kornete (Author), Edward Mason (Author), Roman Istomine (Author), Ciriaco A. Piccirillo (Author)
Format: Book
Published: Taylor & Francis Group, 2017-08-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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