Hypoxic targeting and activating TH-302 loaded transcatheter arterial embolization microsphere

• Main Authors: Pengkai Ma (Author), Jianhua Chen (Author), Haixian Qu (Author), Ye Li (Author), Xiaohui Li (Author), Xuemei Tang (Author), Zhigang Song (Author), Hainan Xin (Author), Jinbang Zhang (Author), Jingxue Nai (Author), Zhiping Li (Author), Zhijun Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The tumor-derived and transcatheter arterial chemoembolization (TACE) induced hypoxia microenvironment is closely related to the poor prognosis of hepatocellular carcinoma (HCC). In this study, hypoxia-activated prodrug TH-302 loaded poly(lactic-co-glycolic acid) (PLGA)-based TACE microspheres were...