A novel Trichinella spiralis serine proteinase disrupted gut epithelial barrier and mediated larval invasion through binding to RACK1 and activating MAPK/ERK1/2 pathway.

• Main Authors: Yan Yan Song (Author), Xin Zhuo Zhang (Author), Bo Ning Wang (Author), Yong Kang Cheng (Author), Xin Guo (Author), Xi Zhang (Author), Shao Rong Long (Author), Ruo Dan Liu (Author), Zhong Quan Wang (Author), Jing Cui (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Gut epithelium is the first natural barrier against Trichinella spiralis larval invasion, but the mechanism by which larval penetration of gut epithelium is not completely elucidated. Previous studies showed that proteases secreted by T. spiralis intestinal infective l...