The epigallocatechin gallate derivative Y6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo

• Main Authors: Yan Wen (Author), Ruiqiang Zhao (Author), Pranav Gupta (Author), Yingfang Fan (Author), Yunkai Zhang (Author), Zhenguang Huang (Author), Xiaohui Li (Author), Yuangang Su (Author), Lijuan Liao (Author), Yu-An Xie (Author), Donghua Yang (Author), Zhe-Sheng Chen (Author), Gang Liang (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previously, we reported that Y6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin (DOX)--mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y6 in reversing drug resistance both in vitro and in vivo by dete...