Peficitinib improves bone fragility by recovering bone turnover imbalance in arthritic mice

• Main Authors: Shingo Sugahara (Author), Kaori Hanaoka (Author), Takashi Emori (Author), Nobuaki Takeshita (Author), Yasutomo Fujii (Author), Masaki Nakano (Author), Takako Suzuki (Author), Jun Takahashi (Author), Yukio Nakamura (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peficitinib, a pan-JAK inhibitor, is known to suppress the activation of fibroblast-like synoviocytes (FLSs) and thereby reduces joint inflammation associated with rheumatoid arthritis (RA). However, the effect on osteoporosis in RA remains to be elucidated. In this study, the effect of peficitinib...