EDiP: the Epitope Dilution Phenomenon. Lessons learnt from a malaria vaccine antigen and its applicability to polymorphic antigens

• Päätekijät: Kwadwo Asamoah Kusi (Tekijä), Bart W. Faber (Tekijä), Gerrit Koopman (Tekijä), Edmond Joseph Remarque (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Introduction: Polymorphism in vaccine antigens poses major challenges to vaccinologists. The Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) poses such a challenge. We found that immunization with a mixture of three variants yielded functional antibody levels to all variants comparable to lev...