Synthesis and antidiabetic activity of β-acetamido ketones
This paper reports the use of trifluoroacetic acid as a catalyst in the Dakin-West reaction for the synthesis of β-acetamido ketones. The method has several advantages such as requiring only mild conditions and a low concentration of catalyst. Screening of 19 β-acetamido ketones for antidiabetic act...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2011-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | This paper reports the use of trifluoroacetic acid as a catalyst in the Dakin-West reaction for the synthesis of β-acetamido ketones. The method has several advantages such as requiring only mild conditions and a low concentration of catalyst. Screening of 19 β-acetamido ketones for antidiabetic activity in vitro showed that their activity as peroxisome proliferator-activated receptor (PPAR) agonists and as dipeptidyl peptidase 4 (DPP-IV) inhibitors was fairly weak. |
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| Item Description: | 2211-3835 2211-3843 10.1016/j.apsb.2011.06.006 |