Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants.

• Main Authors: Anna Maisa (Author), Ute Ströher (Author), Hans-Dieter Klenk (Author), Wolfgang Garten (Author), Thomas Strecker (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Proteolytic processing of the Lassa virus envelope glycoprotein precursor GP-C by the host proprotein convertase site 1 protease (S1P) is a prerequisite for the incorporation of the subunits GP-1 and GP-2 into viral particles and, hence, essential for infectivity and virus spread. Therefore, we test...