Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants.

• Hlavní autoři: Anna Maisa (Autor), Ute Ströher (Autor), Hans-Dieter Klenk (Autor), Wolfgang Garten (Autor), Thomas Strecker (Autor)
• Médium: Kniha
• Vydáno: Public Library of Science (PLoS), 2009-06-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Proteolytic processing of the Lassa virus envelope glycoprotein precursor GP-C by the host proprotein convertase site 1 protease (S1P) is a prerequisite for the incorporation of the subunits GP-1 and GP-2 into viral particles and, hence, essential for infectivity and virus spread. Therefore, we test...