Establishment and clinical validation of an in-cell-ELISA-based assay for the rapid quantification of Rabies lyssavirus neutralizing antibodies.

• Main Authors: Lara Schöler (Author), Vu Thuy Khanh Le-Trilling (Author), Ulf Dittmer (Author), Melanie Fiedler (Author), Mirko Trilling (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neutralizing antibodies (nAbs) prevent the entry of viruses into permissive cells. Since nAbs represent correlates of protection against the Rabies lyssavirus, the presence of sufficient nAbs indicates effective vaccination. Accordingly, Rabies lyssavirus-specific nAb titers need to be determined in...